Topline:
Women consuming at least one sugary drink (SSB) per day have a risk almost five times higher of oral cavity (OCS) cancer than those who consume less than one of these drinks per month. The risk increases to 5.46 times higher in non -smoking women / light smokers and unrelated / light.
METHODOLOGY:
- Over the past three decades, researchers have observed an increased incidence of the WCI among non-smokers, especially in white women in the world. The cause of the OCC among non-smokers does not show any association with the human papillomavirus and is currently unknown.
- The researchers analyzed data from 162,602 women (average age, 43.0 ± 9.9 years) participating in the nursing health study (1986-2016) and the nursing health study (1991-2017) in the United States.
- Participants were followed by the return of a reference questionnaire “until diagnosis of mouth cancer, death or the end of follow -up”, according to the first possibility. Those who have a history of cancer, an incredible calorie intake (<600 ou> 3500 kcal / d) or missing SSB admission data have been excluded from participation in this study.
- The analysis used proportional risk regression models COX with the age and the period of questionnaire as a time scale to estimate risk reports (HR) and 95% CIS for the OCS risk.
- The SSB intake has been quantified by a frequency ranging from <1 SSB per month to ≥ 1 SSB per day, with <1 SSB per month as a reference group.
TAKE AWAY:
- During 30 years of follow-up, 124 WOI invasive cases were documented, participants consuming a daily group ≥ 1 SSB showing an HR of 4.87 (95%CI, 2.47-9.60) compared to the monthly group <1 SSB.
- Risk for the WOI in non-smokers / light smokers and unaware of the light had an HR of 5.46 (95%CI, 1.75-17.07) with ≥ 1 SSB per day vs <1 SSB monthly.
- The analysis of the oral language sub-sites revealed an HR of 4.53 (95%CI, 1.85-11.11) in the daily group ≥ 1 SSB compared to the monthly group <1 SSB.
- Tongue subsites showed an HR of 5.24 (95%CI, 1.84-14.91) in the daily group ≥ 1 SSB A compared to the monthly group <1 SSB.
IN PRACTICE:
“Although the increase in risk seems substantial when it is reported as a relative value, in particular in non -smoking patients or light smokers and unrelated to alcohol, the absolute reference risk is low (3 more cases per 100,000 inhabitants) … These results must be put in a clinical context and suggest that larger cohorts are necessary to assess the role of different food models in patients with patients with patients traditional, ”wrote the authors of the study.
SOURCE:
The study was led by Luis Gomez-Castillo, BA, University of Washington School of Medicine from Seattle. It was published online on March 13 in Jama Otolaryngology – Head and neck surgery.
BOUNDARIES:
According to the authors, estimates lack precision due to the small number of events. The study has only included women, which limits generalization to male patients. In addition, the evaluation of histopathology was limited due to the age and number of samples. Participants in the study were mainly of European origin, requiring an examination of these associations in racial and ethnically diverse populations.
Disclosure:
The study received support through UM1 CA186107 subsidies, PO1 CA87969 and UM1 CA176726 of the National Institutes of Health. The authors have not pointed out any conflict of relevant interests.
This article was created using several editorial tools, including AI, as part of the process. Human publishers examined this content before the publication.
(Tagstotranslate) oto-rhino-laryngology
